With a special focus on screening and prevention, grants were awarded for Career Development, Basic Science, and Translational Research. Since 2004 The Harry J. Lloyd Charitable Trust granted 144 melanoma research grants totaling $17,972,631.
Recipients of Lloyd Trust melanoma grants have conducted research around the world in countries including Argentina, Australia, Belgium, Germany, Greece, Israel, Italy, Spain, Sweden, Switzerland, The Netherlands, the United Kingdom, and The United States of America. With a special focus on screening and prevention, most individual grants do not exceed $125,000 per year.
Scientific Advisory Board
Michael L. Meyers, M.D., Ph.D., Chair
Allan Halpern, M.D.
John Kirkwood, M.D.
Richard Marais, Ph.D.
Ann Richmond, Ph.D.
Paul Tumeh, M.D.
Previous Award Recipients
2021
Primary Investigator: Mohammad Fallahi-Sichani
Project Title: Targeting Cell Plasticity to Overcome Resistance to Melanoma Therapies
Primary Investigator: Michael Pacold
Project Title: Microenvironmental Metabolic Adaptations that enable Melanoma Metastasis
Primary Investigator: Debjani Pal
Project Title: Identification of a Novel Regulator of Cellular Apoptotic Pathways and Therapeutic Target in Melanoma
Primary Investigator: Veronica Rotemberg
Project Title: Prospective Validation of an Open Source Artificial Intelligence Algorithm for Melanoma Diagnosis
Primary Investigator: Megan Ruhland
Project Title: Melanoma Antigen Dispersal Pathways in the Lymph Node Direct Anti-tumor T Cell Reactivity
Primary Investigator: George Souroullas
Project Title: The Role of an Ezh2/Stat3 Interaction in the Melanoma Immune Response
Primary Investigator: Joshua Veatch
Project Title: The Role of Neoantigen Specific CD4+ T Cells in Anti-melanoma Immunity
2020
Primary Investigator: Neil Ganem
Project Title: Defining the Role of the Hippo Tumor Suppressor Pathway in Melanomagenesis
Primary Investigator: Karen Hastings
Project Title: MHC Class II Presentation in Melanoma: Impact on Immune Recognition
Primary Investigator: Robert Judson-Torres
Project Title: Novel Strategies for the Detection and Therapeutic Intervention of Acral Melanoma
Primary Investigator: Deborah Lang
Project Title: Transcriptional Mechanisms Underlying the Shared and Unique Roles of YAP and TAZ in Melanoma
Primary Investigator: Kathryn Miller-Jensen
Project Title: Deciphering Intercellular Networks Regulating Anti-tumor Immunity in Melanoma
Primary Investigator: Michele Teng
Project Title: Targeting MR1 as a Novel Immunotherapy for Melanoma
Primary Investigator: Sara Valpione
Project Title: Biomarkers and Mechanisms of Response to Immunotherapy in Metastatic Melanoma: a Single Cell T Cell Subset Study
2019
Primary Investigator: Hannah Carter
Project Title: Characterizing Germline and Somatic Determinants of Anti-tumor Immunity in Melanoma
Primary Investigator: Rony Dahan
Project Title: Toward Next-generation Checkpoint Antiobodies for Melanoma Immunotherapy
Primary Investigator: Florian Karreth
Project Title: Examining the Therapeutic Potential of the Canonical and Non-canonical Functions of PTEN in Melanoma
Primary Investigator: Berta Lopez Sanchez-Laorden
Project Title: Interplay Between Melanoma Cells and the Neuroimmune System Role in Melanoma Brain Metastases
Primary Investigator: Santoaha Vardhana
Project Title: Altered Cellular Metabolism Promotes Immune Dysfunction in Melanoma
2018
Primary Investigator: Praveen Agrawal
Project Title: Glycosylation as a Regulator of Tropism of Melanoma Metastasis
Primary Investigator: Elizabeth Buchbinder
Project Title: Targeting Tumor Associated Macrophages through CSF1R Inhibition to Overcome BRAF/MEK Resistance in Patients with Metastatic Melanoma
Primary Investigator: Burles Johnson
Project Title: Targeting Indoleamine 2,3 Diosygenase to Augment Anti-melanoma Immunity
Primary Investigator: Eric Lau
Project Title: The Role of HLA-A and HLA-DRB1 Fucosylation in CD4+ T Cell-mediated Suppression of Melanoma
Primary Investigator: Rina Platner
Project Title: Identifying Novel Drug Targets in Melanoma
Primary Investigator: H. Peter Soyer
Project Title: Improving Sun Protection Behavior in Young Australian Adults Using a Digital Behavioral Invention
Primary Investigator: Sara Valpione
Project Title: Biomarkers and Mechanisms of Response to Immunotherapy in Metastatic Melanoma a T Cell Focused Study
2017
Primary Investigator: Elliot Coups
Project Title: An Online Intervention for Skin Self-Examination among Individuals at Increased Risk for Melanoma
Primary Investigator: Diwakar Davar
Project Title: Assessment of Tumor Micro-Environment and Type I IFN Signaling with Pembrolizumab-Pegylated IFN Combination in Advanced Melanoma
Primary Investigator: Berta Lopez Sanchez-Laorden
Project Title: Interplay Between Melanoma Cells and the Neuroimmune System Role in Melanoma Brain Metastases
Primary Investigator: Jose Orgaz
Project Title: Understanding how Cytoskeletal Remodeling leads to Drug Resistance in Melanoma
Primary Investigator: Janis Taube
Project Title: Multiplex Biomarkers for Response to PD-1/PD-L1 Checkpoint Blockade
Primary Investigator: Anna Vilgelm
Project Title: Inducing Therapeutic Senescence via CDKN2A Pathway Reactivation to Combat Melanoma Progression
2016
Primary Investigator: Maria Romina Girotti
Project Title: Role of Galectin/Glycan Interactions in Melanoma Response to Therapy
Primary Investigator: Ping-Chih Ho
Project Title: Deciphering the Role of Immunometabolic Editing on Governing Tumor Cell Aggressiveness and Immune Evasion
Primary Investigator: Aerts Stein
Project Title: Modeling the Dynamic Landscape of Phenotype Switching in Melanoma
Primary Investigator: Efstratios Stratikos
Project Title: Modulating Neoantigen Epitope Generation for Melanoma Immunotherapy
Primary Investigator: Fayyaz Sutterwala
Project Title: Control of Melanoma Progression by NLRC4 and the Microbiome
Primary Investigator: Richard White
Project Title: How Do Adipocytes in the Melanoma Microenvironment Affect Metastasis?
Primary Investigator: Anna Vilgelm
Project Title: Inducing Therapeutic Senescence via CDKN2A Pathway Reactivation to Combat Melanoma Progression
2015
Primary Investigator: Emily Bernstein
Project Title: Melanoma Oncogene Discovery via an Epigenetic Approach
Primary Investigator: Allie Grossmann
Project Title: Elucidating the Role of the Small GTPase ARF6 in Melanoma
Primary Investigator: Nicholas Huntington
Project Title: Effective Melanoma Immunity by Targeting a Suppressor of Natural Killer Cell Signaling
Primary Investigator: Jeff Pawlikowski
Project Title: Manipulating the Senescence Associated Secretory Phenotype to Reinforce Tumor Suppression in Melanoma
Primary Investigator: Tomer Shlomi
Project Title: Targeting Melanoma via MTAP Synthetic Lethality
Primary Investigator: Anna Vilgelm
Project Title: Inducing Therapeutic Senescence via CDKN2A Pathway Reactivation to Combat Melanoma Progression
Primary Investigator: Yuhang Zhang
Project Title: Reprogramming the Tumor Microenvironment to Treat Melanoma
2014
Primary Investigator: Ronen Marmorstein
Project Title: Structure-based Development of STAT 3 Inhibitors in Melanoma
Primary Investigator: Darren Mays
Project Title: Biobehavioral Melanoma Risk Prevention
Primary Investigator: David Mullins
Project Title: Combinational Therapy of Metastatic BRAFV600E T Cells and Vemurafenib
Primary Investigator: Marcelo Murai
Project Title: DUBs as Therapeutic Targets in Malignant Melanoma
Primary Investigator: Elizabeth Repasky
Project Title: De-stressing Immunotherapy for Melanoma: Evaluating the Role of ß-adrenergic Signaling in Immunosupression
Primary Investigator: Monica Rodolfo
Project Title: Prognostic Significance of Myeloid Derived Suppressor Cells and of Immunosuppressive microRNA in Melanoma
Primary Investigator: Nancy Thomas
Project Title: The Role of Interleukin-2 Inducible T Cell Kinase in Cutaneous Melanoma
Primary Investigator: Matthew Van Brocklin
Project Title: Assessing a Role of RalGDS/Ral in Melanoma Maintenance
Primary Investigator: Thomas Wiesner
Project Title: Evaluating the Frequency, Biology, and Therapeutic Relevance of Kinase Fusions in Melanoma
Primary Investigator: Jedd Wolchok
Project Title: Tumor Mutational Landscape and Response to Checkpoint Blockade in Metastic Melanoma
Primary Investigator: Kris Wood
Project Title: Systematically Interrogating the Pathways of Resistance in BRAF-mutant Melanoma
Primary Investigator: Bin Zheng
Project Title: Down-regulation of AMPK Signaling as a Mechanism Linking Obesity and Risk of Malignant Melanoma
2013
Primary Investigator: Paul A. Antony
Project Title: The Role of Negative Costimulatory Receptors during Melanoma Recurrence
Primary Investigator: Roger S. Lo
Project Title: Overcoming Distinct Mechanisms of Acquired B-RAF Inhibitor Resistance in Melanoma Patients by Rational Combinatorial Targeting
Primary Investigator: Ronen Marmorstein Project Title: Structure-based Development of STAT 3 Inhibitors in Melanoma
Primary Investigator: Darren Mays
Project Title: Biobehavioral Melanoma Risk Prevention
Primary Investigator: Jeffrey V. Ravetch
Project Title: Enhancing Immunotherapeutic Activity of Agnostic Anti-CD40 Antibodies
Primary Investigator: Monica Rodolfo
Project Title: Prognostic Significance of Myeloid Derived Suppressor Cells and of Immunosuppressive microRNA in Melanoma
Primary Investigator: David Solit
Project Title: Defining the Genetic Basis for the Heterogenous Response to RAF Inhibitors
Primary Investigator: Nancy Thomas
Project Title: The Role of Interleukin-2 Inducible T Cell Kinase in Cutaneous Melanoma
Primary Investigator: Ashani T. Weeraratna
Project Title: Effects of the Aging Microenvironment on Wnt Signaling and Mesenchymal Mimicry
Primary Investigator: Thomas Wiesner
Project Title: Evaluating the Frequency, Biology, and Therapeutic Relevance of Kinase Fusions in Melanoma
Primary Investigator: Kris Wood
Project Title: Systematically Interrogating the Pathways of Resistance in BRAF-mutant Melanoma
2012
Primary Investigator: Paul A. Anthony
Project Title: The Role of Negative Costimulatory Receptors during Melanoma Recurrence
Primary Investigator: Barbara Bedogni
Project Title: Notch1/MT1-MMP Cross-talk in the Pathogenesis of Melanoma
Primary Investigator Amit Garg
Project Title: The Integrated Skin Exam
Primary Investigator: Roger S. Lo
Project Title: Overcoming Distinct Mechanisms of Acquired B-RAF Inhibitor Resistance in Melanoma Patients by Rational Combinatorial Targeting
Primary Investigator: Poulikos I. Poulikakos
Project Title: Identification of Effective Therapeutic Strategies Against RAF-inhibitor Resistant Melanomas
Primary Investigator: Jeffrey V. Ravetch
Project Title: Enhancing Immunotherapeutic Activity of Agnostic Anti-CD40 Antibodies
Primary Investigator: Ashani T. Weeraratna
Project Title: Effects of the Aging Microenvironment on Wnt Signaling and Mesenchymal Mimicry
Primary Investigator: Weiming Yuan
Project Title: Developing a Cd1d-humanized Mouse Model for Identification of Anti-melanoma Lipid Ligands Targeting NKT Cells
Primary Investigator: Leonard I. Zon
Project Title: Signaling to Hox Genes Drives Uveal Melanoma
2011
Primary Investigator: Jami Garcia-Anoveros
Project Title: MCOLN3 in Melanoma
Primary Investigator: Amit Garg
Project Title: The Integrated Skin Examination: An Educational Intervention Developed to Enhance the Ability and Willingness of Medical Students in Examining the Skin for Melanoma
Primary Investigator: Levi Garraway
Project Title: Functional Dissection of MyD88- and CK2-dependent Signaling in Melanoma
Primary Investigator: Beatrix Kotlan
Project Title: B Cells on the Road to Defeat Cancer: Revealing the Tumor Antigen Recognition and Functional Capacities of B Lymphocytes in Melanomas
Primary Investigator: Rajmohan Murali
Project Title: Genomic Analysis of Desmoplastic Melanoma to Identify Novel Oncogenic Driver Mutations Using Next-generation Approaches
Primary Investigator: Keiran Smalley
Project Title: Axl: A Novel Therapeutic in NRAS-mutated Melanoma
Primary Investigator: Samra Turajlic
Project Title: Acral Melanoma: Discovery of Novel Drivers and Therapeutic Targets
Primary Investigator: Weiming Yuan
Project Title: Developing a CD1d-humanized Mouse Model for Identification of Anti-melanoma Lipid Ligands Targeting NKT Cells
2010
Primary Investigator: Rutao Cui
Project Title: Pigmentation and DNA Repair in Melanoma
Primary Investigator: Colin R. Godding
Project Title: The Role of BRAF-driven MIFT Acetylation in Melanoma Heterogeneity
Primary Investigator: Eva Hernando
Project Title: Role of the miR-182-96-183 Cluster in Melanocyte Differentiation and Melanoma Pathogenesis
Primary Investigator: Beatrix Kotlan
Project Title: B Cells on the Road to Defeat Cancer: Revealing the Tumor Antigen Recognition and Functional Capacities of B Lymphocytes in Melanomas
Primary Investigator: Nita Maihle
Project Title: A Preclinical Study of p45-sHER3: A Putative Metastatis Factor in Melanoma
Primary Investigator: Michele Maio
Project Title: Prognostic Relevance and Perspective Therapeutic Implications of the DNA “Methylome” in Human Cutaneous Melanoma
Primary Investigator: Janice Mehnert
Project Title: A Phase 0 Trial of Hydroxychloroquine in Patients with Stage III and IV Resectable Melanoma
Primary Investigator: David Stern
Project Title: Identifying New Targets for Personalizing Melanoma Therapies
Primary Investigator: Hensin Taso
Project Title: Governance of Cutaneous Photocarcinogenesis by Chronic UVA- exposedDermal Fibroblasts
Primary Investigator: Samra Turajlec
Project Title: Acral Melanoma: Discovery of Novel Drivers and Therapeutic Targets
Primary Investigator: Claudia Wellbrock
Project Title: Identification in vivo Characterisation of Melanoma Specific MITF / Cytoskeleton Interactin
2009
Primary Investigator: Rutao Cui
Project Title: Pigmentation and DNA Repair in Melanoma
Primary Investigator: Colin R. Godding
Project Title: The Role of BRAF-driven MIFT Acetylation in Melanoma Heterogeneity
Primary Investigator: Eva Hernando
Project Title: Role of the miR-182-96-183 Cluster in Melanocyte Differentiation and Melanoma Pathogenesis
Primary Investigator: Roya Khosravi-Far
Project Title: Novel Strategy for the Treatment of Malignant Melanoma
Primary Investigator: Michele Maio
Project Title: Prognostic Relevance and Perspective Therapeutic Implications of the DNA Methylome” in Human Cutaneous Melanoma
Primary Investigator: Leisl Packer
Project Title: Identification and Characterization of Downstream Targets of Oncogenic BRAF and Brn-2 in Melanoma
Primary Investigator: Keiran S. Smelly
Project Title: Organometallic Protein Kinase Inhibitors as Chemosensitizers in Melanoma
Primary Investigator: David F. Stern
Project Title: Identifying New Targets for Personalizing Melanoma Therapies
Primary Investigator: Cassian Eye
Project Title: The Use of Il-21-modulated CTL for Adoptive T Cell Therapy
2008
Primary Investigator: Lynne T. Bemis
Project Title: MITF and MicroRNAs as Prognostic Indicators and Targets in Melanoma
Primary Investigator: Jonathan S. Cebon
Project Title: Immune Targeting of Melanoma Stem Cells
Primary Investigator: Julide Tok Celebi
Project Title: The Genetic Basis of the 5p15 Amplification in Melanoma
Primary Investigator: Tanja de Gruijl
Project Title: Releasing the brakes on CD8+ T cells in the melanoma sentinel lymph node by pre-operative local administration of low-dose anti-CTLA4
Primary Investigator: Thomas M. Guadagno
Project Title: Role for Oncogenic B-Raf in Driving Aneuploidy during Melanoma Development
Primary Investigator: Pablo Lopez Bergami
Project Title: Regulation of PDK1 Expression by C-Jun in Melanoma: Its Impact on Major Signaling Pathways and on Melanoma Tumorigenesis
Primary Investigator: Ashfaq Marghoog
Project Title: Developing the optimal melanoma screening tutorial for primary care physicians and medical students
Primary Investigator: Stergios Moschos
Project Title: Regulation of Aurora Kinase B by Ubc9 in Melanoma
Primary Investigator: Leisl Packer
Project Title: Identification and characterisation of downstream targets of oncogenic BRAF and Brn-2 in melanoma
Primary Investigator: Antoni Ribas
Project Title: Immunosensitization of Malignant Melanoma
Primary Investigator: Licia Rivoltini
Project Title: IL-13/IL-13R pathway; a potential new target for melanoma therapy
Primary Investigator: Yardena Samuels
Project Title: Mutational Analysis of the Phosphatase Gene Family in Cutaneous Malignant Melanoma
2007
Primary Investigator: Lynne T. Bemis
Project Title: MITF, a MicroRNA Target in Melanoma
Primary Investigator: Jonathan S. Cebon
Project Title: Immune Targeting of Melanoma Stem Cells
Primary Investigator: Julide Tok Celebi
Project Title: The Genetic Basis of the 5p15 Amplification in Melanoma
Primary Investigator: Elieser Gorelik
Project Title: Multiplex Analysis of Serum Biomarkers for Prediction Interferon Therapy Response in Melanoma Patients
Primary Investigator: Thomas M. Guadagno
Title: Molecular and Translational Studies on Oncogenic B-RafV600E in Melanoma
Primary Investigator: Antoni Ribas
Project Title: Immunosensitization of Malignant Melanoma
Primary Investigator: Hua E. Yu
Project Title: Targeting Stat3 to Improve Melanoma Immunotherapies
2006
Primary Investigator: Anja K. Bosserhoff
Project Title: Evaluation of Novel Prognostic Marker for Malignant Melanoma.
Primary Investigator: Mitchell F. Denning
Project Title: Protein Kinase C as a Selective Therapeutic Target for Melanoma
Primary Investigator: Jianli Dong
Project Title: BRAF and INK4A Lesions as Potential Targets in Melanoma Treatment
Primary Investigator: Thomas F. Gajewski
Project Title: Randomized Phase II Study of Multipeptide Vaccination with or without Regulatory T Cell Depletion Using Ontak in Patients with Metastatic Melanoma
Primary Investigator: Allan C. Geller
Project Title: Sun Protection Communication Practices Among High-Risk Families
Primary Investigator: Elieser Gorelik
Project Title: Multiplex Analysis of Serum Biomarkers for Prediction Interferon Therapy Response in Melanoma Patients
Primary Investigator: Gregory B. Lesinski
Project Title: The Role of Jak-STAT signal Transduction in Mediating the Pro-Apoptotic Effects of Bortezamib and Interferon-Alpha on Melanoma Cells
Primary Investigator: Janiel M. Shields
Project Title: EGFR and RND3: Therapeutic Targets in Melanoma
Primary Investigator: Hua E. Yu
Project Title: Targeting Stat3 to Improve Melanoma Immunotherapies
2005
Primary Investigator: Aka Borg
Project Title: Genetic Analysis and Genomic Profiling of Malignant Melanoma for Detection of New Predisposing Genes and Tumor Signatures of Poor Prognosis
Primary Investigator: Anja K. Bosserhoff
Project Title: Evaluation of MTAP as a Prognostic Marker for Malignant Melanoma and a Predictive Marker for the Success of Interferon-based Therapies
Primary Investigator: Clara Curiel-Lewandrowski
Project Title: Statins as Chemopreventive Agents in Malignant Melanoma
Primary Investigator: Robert M. de Waal
Project Title: The Mechanism of Melanoma Metastasis
Primary Investigator: Jianli Dong
Project Title: BRAF and INK4A Lesions as Potential Targets in Melanoma Treatment
Primary Investigator: Peter P. Lee
Project Title: Mechanisms of Lymph Node Invasion by Melanoma
Primary Investigator: Susan A. Oliveria
Project Title: Melanoma Survivors: Health Behaviors, Surveillance, Psychosocial Factors, and Family Concerns
Primary Investigator: Pamela Pollock
Project Title: Investigating the Role of FGFR2 in Melanoma Progression
Primary Investigator: Andrew M. Scott
Project Title: Immunobiology of Recombinant Antibodies for the Therapy of Metastatic Melanoma
Primary Investigator: Susan M. Swetter
Project Title: Reaching out to Middle-aged and Older Men to Improve Melanoma Awareness and Early Detection
Primary Investigator: Kathy Yao
Project Title: Notch Signaling in Cutaneous Melanoma: A Pilot Study
2004
Primary Investigator: Clara Curiel-Lewandrowski
Project Title: Statins as Chemopreventive Agents in Malignant Melanoma
Primary Investigator: Soldano Ferrone
Project Title: Molecular Mimicry and Immunotherapy of Melanoma
Primary Investigator: Peter P. Lee
Project Title: Mechanisms of Lymph Node Invasion by Melanoma
Primary Investigator: Richard Marais
Project Title: The Regulation of Senescence by Oncogenic B-RAF in Melanocytes
Primary Investigator: Dirk Schadendorf
Project Title: Clinical Phase I Study of Alpha-type-1 Dendritic Cells in Melanoma Patients
Primary Investigator: Andrew M. Scott
Project Title: Immunobiology of Recombinant Antibodies for the Therapy of Metastatic Melanoma
Primary Investigator: Susan M. Swetter
Project Title: Reaching Out to Middle-Aged and Older Men to Improve Melanoma Awareness and Early Detection
